The spectacular development of medical knowledge over the last two centuries has brought intrusive advances in the capabilities of medical technology. These advances have been remarkable over the last century, but especially over the last few decades, culminating in such high technology interventions as heart transplants and renal dialysis. These increases in medical powers have attracted societal interest in acquiring more such knowledge. They have also spawned concerns regarding the use of human subjects in research and regarding the byproducts of (...) basic research as in the recent recombinant DNA debate. As a consequence of the development of new biomedical knowledge, physicians and biomedical scientists have been placed in positions of new power and responsibility. The emergence of this group of powerful and knowledgeable experts has occasioned debates regarding the accountability of physicians and biomedical scientists. But beyond that, the very investment of resources in the acquisition of new knowledge has been questioned. Societies must decide whether finite resources would not be better invested at this juncture, or in general, in the alleviation of the problems of hunger or in raising general health standards through interventions which are less dependent on the intensive use of high technology. To put issues in this fashion touches on philosophical notions concerning the claims of distributive justice and the ownership of biomedical knowledge. (shrink)

The epithet χαλκοκραυνον has perturbed many, though the most recent English editors have printed it without comment. The new Liddell and Scott betrays uneasiness in its ‘epithet of the sea, perhaps false reading for χαλκαμρυγος, gleaming like copper or bronze’. Overseas scholars flatly reject it. Wilamowitz poured scorn on it in his Interpretationen and commented in his larger edition neque intelligitur et frustra temptatum est. Weir Smyth obelizes it. Bothe, Hermann, Weil, and others offered emendations. In Bursians Jahresberichte, ccxxxiv, (...) p. 104 W. Morel observed Von Erz und Blitz befreit uns Bruhns χλιαρκρουνον. This is emancipation indeed. (shrink)

West takes his title from Camus, and quotes Camus' definition of absurdity: "the division between the mind that desires and the world that disappoints." The essays, which originally appeared in periodicals, discuss Yeats, Lawrence, Sartre, Camus, Simon Weil, Graham Greene, Santayana, and other modern writers. There is no analysis, either philosophical or literary; West attempts overall estimates of each writer's contribution to the problem of absurdity, but succeeds in providing neither insights for those already familiar with the problem nor (...) useful introductions for the uninitiated. Nor, despite the expectations aroused by the preface, do we get a very strong impression of an individual's encounter with the thinkers from whom he has learned most. In vino vacuitas.—W. B. K. (shrink)

West takes his title from Camus, and quotes Camus' definition of absurdity: "the division between the mind that desires and the world that disappoints." The essays, which originally appeared in periodicals, discuss Yeats, Lawrence, Sartre, Camus, Simon Weil, Graham Greene, Santayana, and other modern writers. There is no analysis, either philosophical or literary; West attempts overall estimates of each writer's contribution to the problem of absurdity, but succeeds in providing neither insights for those already familiar with the problem nor (...) useful introductions for the uninitiated. Nor, despite the expectations aroused by the preface, do we get a very strong impression of an individual's encounter with the thinkers from whom he has learned most. In vino vacuitas.—W. B. K. (shrink)

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

Psychologists' emerging interest in spirituality and religion as well as the relevance of each phenomenon to issues of psychological importance requires an understanding of the fundamental characteristics of each construct. On the basis of both historical considerations and a limited but growing empirical literature, we caution against viewing spirituality and religiousness as incompatible and suggest that the common tendency to polarize the terms simply as individual vs. institutional or ′good′ vs. ′bad′ is not fruitful for future research. Also cautioning against (...) the use of restrictive, narrow definitions or overly broad definitions that can rob either construct of its distinctive characteristics, we propose a set of criteria that recognizes the constructs' conceptual similarities and dissimilarities. Rather than trying to force new and likely unsuccessful definitions, we offer these criteria as benchmarks for judging the value of existing definitions. (shrink)

This is the first book to offer the best essays, articles, and speeches on ethics and intelligence that demonstrate the complex moral dilemmas in intelligence collection, analysis, and operations. Some are recently declassified and never before published, and all are written by authors whose backgrounds are as varied as their insights, including Robert M. Gates, former Director of the Central Intelligence Agency; John P. Langan, the Joseph Cardinal Bernardin Professor of Catholic Social Thought at the Kennedy Institute of Ethics, Georgetown (...) University; and Loch K. Johnson, Regents Professor of Political Science at the University of Georgia and recipient of the Owens Award for contributions to the understanding of U.S. intelligence activities. Creating the foundation for the study of ethics and intelligence by filling in the gap between warfare and philosophy, this is a valuable collection of literature for building an ethical code that is not dependent on any specific agency, department, or country. (shrink)

W. E. B. Du Bois was a public intellectual, sociologist, and activist on behalf of the African American community. He profoundly shaped black political culture in the United States through his founding role in the NAACP, as well as internationally through the Pan-African movement. Du Bois's sociological and historical research on African-American communities and culture broke ground in many areas, including the history of the post-Civil War Reconstruction period. Du Bois was also a prolific author of novels, autobiographical accounts, innumerable (...) editorials and journalistic pieces, and several works of history. Collected in one volume for the first time, The World and Africa and Color and Democracy are two of W E. B. Du Bois's most powerful essays on race. He explores how to tell the story of those left out of recorded history, the evils of colonialism worldwide, and Africa's and African's contributions to, and neglect from, world history. More than six decades after W. E. B. Du Bois wrote The World and Africa and Color and Democracy, they remain worthy guides for the twenty-first century. With a series introduction by editor Henry Louis Gates, Jr., and two introductions by top African scholars, this edition is essential for anyone interested in world history. (shrink)

Recent reports of the discovery of a “God module” in the human brain derive from the fact that epileptic seizures in the left temporal lobe are associated with ecstatic feelings sometimes described as an experience of the presence of God. The brain area involved has been described as either (a) the seat of an innate human faculty for experiencing the divine or (b) the seat of religious delusions.In fact, religious experience is extremely various and involves many parts of the brain, (...) including some that are prehuman in their evolutionary history and some that are characteristically human. In the continuing integration of such experiences, spiritual formation takes place. Thus the entire human brain might be described as a “God module.”Such a process is only possible because of the brain's complexity. The human brain is the most complex entity for its size that we know of. As used here, complexity is a specialized term denoting the presence of a web of interlinked and significant connections—the more intricate the web, the more complex the entity. Complex systems develop only in a milieu that provides both lawfulness and freedom, and they tend to be self‐organizing, becoming more complex and more effective as a result of both inward and outward experience. The evidence suggests that both personal growth and spiritual growth are processes of complexification of character, and of the brain itself. This thesis is tested in light of the work of William James and James W. Fowler. (shrink)

The late Jacob Klein’s important book is, remarkably, a lucid presentation of esoteric argument. Dealing with the famed Platonic triad, Theaetetus, Sophist, and Statesman, Klein settles the dispute about the missing dialogue, "The Philosopher," by first denying that it is missing and second showing that it is unnecessary. He argues, in short, that the triad is a dyad. That argument is reinforced by the distinction Klein strongly implies between the Socratic Theaetetus and the Eleatic Sophist and Statesman. "We can now (...) understand why the conversations of the ‘trilogy’ occur in two, not three, days and why the Sophist, the Statesman, and the Philosopher are dealt with in two, not three, dialogues". (shrink)

"Bibliographical notes": pages [243]-244.

© 2015 Elsevier Inc.Postnatal organogenesis occurs in an immune competent environment and is tightly controlled by interplay between positive and negative regulators. Innate immune cells have beneficial roles in postnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored. Here we show that adaptive immune responses participate in the normal postnatal development of a non-lymphoid epithelial tissue. Since the mammary gland is the only organ developing predominantly after birth, we utilized it as a powerful system to study (...) adaptive immune regulation of organogenesis. We found that antigen-mediated interactions between mammary antigen-presenting cells and interferon-γ -producing CD4+ T helper 1 cells participate in MG postnatal organogenesis as negative regulators, locally orchestrating epithelial rearrangement. IFNγ then affects luminal lineage differentiation. This function of adaptive immune responses, regulating normal development, changes the paradigm for studying players of postnatal organogenesis and provides insights into immune surveillance and cancer transformation. Plaks et al. (shrink)

Dieser Band präsentiert, gemeinsam mit anderen Beiträgen, die anlässlich der Gedenkfeier zum 100. Geburtstag von Leo Gabriel gehaltenen Vorträge am Institut für Philosophie der Universität Wien. Lange vor den gegenwärtigen Bestrebungen zu einer europäischen Integration hat Gabriel die Entwicklung der geistigen Gestalten Europas und das Verhältnis von Einheit und Vielheit integrativ zu erfassen versucht. Die Autorinnen und Autoren erörtern die Quellen sowie die Aktualität des integralen Denkens und vergleichen es mit phänomenologisch-existentialistischen, hermeneutischen, strukturalistischen und postmodernen Theorien. Überdies beinhaltet der Band (...) Zeugnisse und unveröffentlichte Manuskripte von Leo Gabriel. Aus dem Inhalt: Peter Kampits: Vorwort - Yvanka B. Raynova: Einleitung: Verantwortung für das Ganze - Leo Gabriel: Gestalten und Strukturen des integrativen Denkens - Leo Gabriel: Wissenschaft und Wertordnung (Unveröffentlichtes Manuskript) - Leo Gabriel Jr.: Von der Suche nach dem Ganzen zur Sucht nach Veränderung - Augustinus Karl Wucherer-Huldenfeld: Zur Aktualität des integralen Denkens Leo Gabriels - Sigrid Pöllinger: Wladimir S. Solowjew und der Begriff der All-Einheit - Günther Pöltner: Radikale Pluralität. Zur Problematik eines postmodernen Paradigmas - Yvanka B. Raynova: Integrales Denken im europäischen Kontext: Gabriel - Heidegger - Ricoeur - Roland Faber: "Insistenz". Zum "Nicht-Sein" Gottes bei Levinas, Deleuze und Whitehead - Rolf Kühn: Sinnlichkeit als Offenbarung. Eine phänomenologische Analyse zum Denken Simone Weils - Karl Baier: Der Mensch als Person und Anatman. Überlegungen zu einer Grundfrage im buddhistisch-christlichen Dialog - Werner Gabriel: Philosophisches Denken als Weg der Erlösung. Ein interkultureller Vergleich - Arno Böhler: Über die Dummheit: Einblick in den Abgrund des Denkens - Jürgen Trinks: Das offene Feld der Phantasie und die Fallstricke der Einbildung - Laurie Calhoun: The Paradox of Love and the Paradox of Morality: Triangular Reflections in Carol Reed's "The Third Man" - Yvanka B. Raynova: Leo Gabriel: Eine ausgewählte Bibliographie. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Future Directions for Human Cloning by Embryo Splitting:After the HullabalooCynthia B. Cohen (bio)In October 1993, a paper entitled, "Experimental Cloning of Human Polyploid Embryos Using an Artificial Zona Pellucida," was presented at a joint meeting of the American Fertility Society and the Canadian Fertility and Andrology Society. Although it was awarded a prize, its authors, who are affiliated with George Washington University, decided against calling a press conference to (...) announce their findings. Word of their experiment soon leaked out, however, and the New York Times blazoned on its front page that human embryo cloning had been achieved. The story was accompanied by a diagram of cloning by nuclear transplantation.Newspapers and television networks around the world picked up the story and embellished it. The idea of unlimited, xeroxed copies of human beings gripped the public imagination. Wild scenarios of hundreds of Hitlers plotting to take over the world and of clones giving birth to their own twins enlivened media reports. Only gradually did it become clear that the term "polyploid" in the title of the paper referred to abnormal embryos that could never develop into living human beings and that "cloning" referred to embryo splitting or twinning, not to nuclear transplantation or the transfer of a donor nucleus into an enucleated egg. Once this sank into public consciousness, the "hullabaloo," as Dr. Howard W Jones, Jr., called it, died down.It left in its wake unanswered questions about the ethics of splitting embryos. During the height of the publicity given to the George Washington experiment, newspaper and TV stories had not delved in any depth into the ethical issues it raised. Ethicists, given limited time to discuss the ethical questions at stake, had been quoted in quick, simplistic responses. Some had offered little analysis of the rights and wrongs of embryo splitting, but, revealing tremendous creative talent, had spun out [End Page 187] imaginary and frightening applications of the procedure. This was a story essentially about ethics in which ethics was never really discussed.The National Advisory Board on Ethics in Reproduction* (NABER), an independent, multidisciplinary group that addresses ethical issues in modern reproductive science, technology, and care, became concerned about the sparsity of reflective ethical debate about embryo splitting. NABER's chair, Albert Jonsen, observed that "reporters phoning ethicists for comment and ethicists appearing on talk shows do not a debate make. Debate requires face to face (or at least essay to essay) argument among persons sharing the same information. This has yet to take place." Consequently, NABER decided to convene a workshop on human cloning by embryo splitting at the National Academy of Sciences in February 1994. The board invited participants who would provide a broad range of opinion about the ethical and public policy issues entailed by human embryo splitting. Embryologists, ethicists, reproductive biologists, public policy experts, staff from the National Institutes of Health (NIH), legal scholars, journalists, and infertility specialists were among those who participated. The feature articles in this issue of the Kennedy Institute of Ethics Journal derive from that workshop. Their authors were given free rein to take whatever stance they deemed ethically supportable.The first article is designed to provide some understanding of the science of human cloning as a basis for exploring the ethical issues raised by this set of techniques. Jacques Cohen, a leading reproductive embryologist, and Giles Tomkin, a science writer, both of Cornell University Medical School, explain, in a way that is clear to laypersons and biologists alike, the meaning, nature, and function of cloning. They discuss recent: advances in this area and offer an assessment of feasible uses of human cloning procedures, hoping to dispel what they view as mistaken fears about its future applications. Dr. Howard W Jones, Jr., a pioneer infertility specialist, briefly comments on Cohen and Tomkin's paper, pointing out that embryo splitting may not improve pregnancy results if genetic heterogeneity is required for successful embryo transfer and implantation.In the next article, three major ethical arguments against human cloning by embryo splitting are analyzed and rejected by Ruth Macklin, an expert in reproductive ethics from Albert Einstein College of Medicine. She finds the first argument, that the worth of individuals... (shrink)